Article
A graphene-based platform for fluorescent detection of SNPs.
The Analyst - 7 May 2013
Xu Hui, Yang Qing, Li Fan, Tang Linsheng, Gao Shanmin, Jiang Bowei, Zhao Xingchun, Wang Lihua, Fan Chunhai
Abstract excerpt
A novel fluorescent single nucleotide polymorphism (SNP) assay was developed by using Graphene Oxide (GO), which provides a fast, sensitive and simple method for SNP detection. The strategy was based on the single base extension reaction and different absorption capacity of fluorescein labeled dGTP (dGTP-Fl) and double-stranded DNA (dsDNA) to GO. dGTP-Fl is incorporated into the probe by extension reaction for...
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