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Article

Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.

Disease models & mechanisms - 1 Apr 2015

Herrera José A, Ward Christopher S, Pitcher Meagan R, Percy Alan K, Skinner Steven, Kaufmann Walter E, Glaze Daniel G, Wehrens Xander H T, Neul Jeffrey L

Abstract excerpt

One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpected death. The standard of care for LQT in RTT is treatment with β-adrenergic antagonists; however, recent work indicates that acute treatment of mice with RTT with...

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Identifiers

PMID: 25713300
DOI: 10.1242/dmm.020131
PMCID: PMC4381335

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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