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Article

Repurposing polyamines to prevent life-threatening arrhythmias in Short QT Syndrome type 3.

Nature communications - 20 Jun 2026

Moreno-Manuel Ana I, Cruz Francisco M, Macías Álvaro, Cabrera-Borrego Eva, Jalife José

Abstract excerpt

Short QT Syndrome type 3 (SQTS3) is an inherited disorder marked by an abnormally short QT interval on ECG and a high risk of life-threatening arrhythmias, for which effective targeted therapies are lacking. SQTS3 is caused by Kir2.1 mutations that enhance the outward component of the strong inward rectifier potassium current (IK1), disrupting its normal voltage-dependent regulation and severely abbreviating the...

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Identifiers

PMID: 42323289
DOI: 10.1038/s41467-026-74259-7
PMCID: PMC13439188

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