Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype.

Life sciences - 1 Nov 2022

Souza Diego Santos, Marques Leisiane Pereira, Costa Alexandre Dantas, Cruz Jader Santos, Rhana Paula, Santos-Miranda Artur, Joviano-Santos Julliane Vasconcelos, Durço Aimée Obolari, Vasconcelos Carla Maria Lins, Roman-Campos Danilo

Abstract excerpt

AIMS: Hypothyroidism is associated with an increased risk of cardiovascular disease and enhanced susceptibility to arrhythmias. In our investigation, we evaluated the potential involvement of late sodium current (INa,late) in cardiac arrhythmias in an experimental murine model of hypothyroidism. MAIN METHODS: Male Swiss mice were treated with methimazole (0.1 % w/vol, during 21 days) to induce experimental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Action Potentials
Share to Arrhythmias, Cardiac

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caffeine

Share to Hypothyroidism

Share to Myocytes, Cardiac

Share to Phenotype

Share to Sodium

Source

Identifiers

PMID: 36096245
DOI: 10.1016/j.lfs.2022.120945

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Experimental hypothyroidism induces cardiac arrhythmias and ranolazine reverts and prevents the phenotype.PMID 36096245Read ↗

Ranolazine Prevents Phenotype Development in a Mouse Model of Hypertrophic Cardiomyopathy.Semantic proximity Read ↗

Impaired Ca2+ handling and contraction in cardiomyocytes from mice with a dominant negative thyroid hormone receptor alpha1.Semantic proximity Read ↗

Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na+-channel-blocking antiepileptic drugs.Semantic proximity Read ↗

Thyroid hormone and phenotypes of cardioprotection.Semantic proximity Read ↗

Melatonin as a Potential Antiarrhythmic Drug: Myocardial Ischemia and BeyondSemantic proximity Read ↗

The Impact of a Non-Functional Thyroid Receptor Beta upon Triiodotironine-Induced Cardiac Hypertrophy in Mice.Semantic proximity Read ↗

Central Hypothyroidism Impairs Heart Rate Stability and Prevents Thyroid Hormone-Induced Cardiac Hypertrophy and Pyrexia.Semantic proximity Read ↗

Ranolazine and late cardiac sodium current--a therapeutic target for angina, arrhythmia and more?Semantic proximity Read ↗

Diastolic dysfunction and arrhythmias caused by overexpression of CaMKIIδ(C) can be reversed by inhibition of late Na(+) current.Semantic proximity Read ↗

Late I Na Blocker GS967 Supresses Polymorphic Ventricular Tachycardia in a Transgenic Rabbit Model of Long QT Type 2Semantic proximity Read ↗

A knock-in mouse model of N-terminal R420W mutation of cardiac ryanodine receptor exhibits arrhythmogenesis with abnormal calcium dynamics in cardiomyocytes.Semantic proximity Read ↗

MELATONIN AS A POTENTIAL ANTIARRHYTHMIC DRUG: MYOCARDIAL ISCHEMIA AND BEYONDSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.