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Article

Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy.

Journal of the National Cancer Institute - 1 Apr 2015

Ager Eleanor I, Kozin Sergey V, Kirkpatrick Nathaniel D, Seano Giorgio, Kodack David P, Askoxylakis Vasileios, Huang Yuhui, Goel Shom, Snuderl Matija, Muzikansky Alona, Finkelstein Dianne M, Dransfield Daniel T, Devy Laetitia, Boucher Yves, Fukumura Dai, Jain Rakesh K

Abstract excerpt

BACKGROUND: Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. METHODS: Orthotopic murine breast tumors (4T1 and E0771 with high and low MMP14 expression, respectively; n = 5-10 per group) were treated with an anti-MMP14 inhibitory antibody (DX-2400), IgG control, fractionated radiation therapy, or their combination. We assessed primary tumor growth,...

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Source

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Identifiers

PMID: 25710962
DOI: 10.1093/jnci/djv017
PMCID: PMC4402365

Genes

MMP14
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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