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New signaling pathways from cancer progression modulators to mRNA expression of matrix metalloproteinases in breast cancer cells

23 Feb 2011

Abstract excerpt

We observed previously that each of seven cancer progression inhibitors suppresses the mRNA expression of some matrix metalloproteinases (MMPs), but stimulates that of others, in breast cancer cells. In the present study we tested the effect of overexpressing other cancer modulators on MMP expression. The MMPs tested are MMP1, MMP2, MMP7, MMP13, MMP14, MMP16, MMP19, and MMP25. The proteins that were overexpressed...

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PMID: 21344390
DOI: 10.1002/jcp.22694

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