Article
Low-dose irradiation programs macrophage differentiation to an iNOS⁺/M1 phenotype that orchestrates effective T cell immunotherapy.
Cancer cell - 11 Nov 2013
Klug Felix, Prakash Hridayesh, Huber Peter E, Seibel Tobias, Bender Noemi, Halama Niels, Pfirschke Christina, Voss Ralf Holger, Timke Carmen, Umansky Ludmila, Klapproth Kay, Schäkel Knut, Garbi Natalio, Jäger Dirk, Weitz Jürgen, Schmitz-Winnenthal Hubertus, Hämmerling Günter J, Beckhove Philipp
Abstract excerpt
Inefficient T cell migration is a major limitation of cancer immunotherapy. Targeted activation of the tumor microenvironment may overcome this barrier. We demonstrate that neoadjuvant local low-dose gamma irradiation (LDI) causes normalization of aberrant vasculature and efficient recruitment of tumor-specific T cells in human pancreatic carcinomas and T-cell-mediated tumor rejection and prolonged survival in...
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