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Nuclear Receptors as Therapeutic Targets for Neurodegenerative Diseases: Lost in Translation

12 Sept 2018

Abstract excerpt

Neurodegenerative diseases are characterized by a progressive loss of neurons that leads to a broad range of disabilities, including severe cognitive decline and motor impairment, for which there are no effective therapies. Several lines of evidence support a putative therapeutic role of nuclear receptors (NRs) in these types of disorders. NRs are ligand-activated transcription factors that regulate the...

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PMID: 30208281
DOI: 10.1146/annurev-pharmtox-010818-021807

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