Article
Evidence that mutation accumulation does not cause aging in Saccharomyces cerevisiae.
Aging cell - 1 Jun 2015
Kaya Alaattin, Lobanov Alexei V, Gladyshev Vadim N
Abstract excerpt
The concept that mutations cause aging phenotypes could not be directly tested previously due to inability to identify age-related mutations in somatic cells and determine their impact on organismal aging. Here, we subjected Saccharomyces cerevisiae to multiple rounds of replicative aging and assessed de novo mutations in daughters of mothers of different age. Mutations did increase with age, but their low...
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