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Article

CDKs in Sarcoma: Mediators of Disease and Emerging Therapeutic Targets

24 Apr 2020

Abstract excerpt

Sarcomas represent one of the most challenging tumor types to treat due to their diverse nature and our incomplete understanding of their underlying biology. Recent work suggests cyclin-dependent kinase (CDK) pathway activation is a powerful driver of sarcomagenesis. CDK proteins participate in numerous cellular processes required for normal cell function, but their dysregulation is a hallmark of many pathologies...

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PMID: 32344731
DOI: 10.3390/ijms21083018

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