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Article

Cell-Cycle Gene Alterations in 4,864 Tumors Analyzed by Next-Generation Sequencing: Implications for Targeted Therapeutics.

Molecular cancer therapeutics - 1 Jul 2016

Helsten Teresa, Kato Shumei, Schwaederle Maria, Tomson Brett N, Buys Timon P H, Elkin Sheryl K, Carter Jennifer L, Kurzrock Razelle

Abstract excerpt

Alterations in the cyclin-dependent kinase (CDK)-retinoblastoma (RB) machinery disrupt cell-cycle regulation and are being targeted in drug development. To understand the cancer types impacted by this pathway, we analyzed frequency of abnormalities in key cell-cycle genes across 4,864 tumors using next-generation sequencing (182 or 236 genes; Clinical Laboratory Improvement Amendments laboratory). Aberrations in...

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Source

Identifiers

PMID: 27196769
DOI: 10.1158/1535-7163.MCT-16-0071

Genes

CDK6
CCND1
CCND2
CCND3
CCNE1
CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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