Article
Cyclin alterations in diverse cancers: Outcome and co-amplification network.
Oncotarget - 20 Feb 2015
Schwaederlé Maria, Daniels Gregory A, Piccioni David E, Fanta Paul T, Schwab Richard B, Shimabukuro Kelly A, Parker Barbara A, Kurzrock Razelle
Abstract excerpt
Cyclin genes are key regulatory components of the cell cycle. With the development of new agents, cyclin-related genes are becoming increasingly important as they can be targeted. Yet, the biological implications of these alterations have not been fully studied. Clinical characteristics and outcome parameters were compared for patients harboring cyclin alterations versus not. CCN alterations were found in 13% of...
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