Multigene Panel Next-Generation Sequencing Techniques in the Management of Patients with Metastatic Colorectal Carcinoma: The Way Forward for Personalized Treatment? A Single-Center Experience.

doi:10.3390/ijms252011071

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Multigene Panel Next-Generation Sequencing Techniques in the Management of Patients with Metastatic Colorectal Carcinoma: The Way Forward for Personalized Treatment? A Single-Center Experience.

International journal of molecular sciences - 15 Oct 2024

Matteucci Laura, Sullo Francesco Giulio, Gallio Chiara, Esposito Luca, Muratore Margherita, Rapposelli Ilario Giovanni, Calistri Daniele, Petracci Elisabetta, Rengucci Claudia, Capelli Laura, Chiadini Elisa, Ulivi Paola, Passardi Alessandro, Bittoni Alessandro

Abstract excerpt

The efficacy and cost-effectiveness of Multigene Panel Next-Generation Sequencing (NGS) in directing patients towards genomically matched therapies remain uncertain. This study investigated metastatic colorectal cancer (mCRC) patients who underwent NGS analysis on formalin-fixed paraffin-embedded tumor samples. Data from 179 patients were analyzed, revealing no mutations in 39 patients (21.8%), one mutation in 83...

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PMID: 39456850
DOI: 10.3390/ijms252011071
PMCID: PMC11507460

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