Murine filaggrin‐2 is involved in epithelial barrier function and down‐regulated in metabolically induced skin barrier dysfunction

Abstract excerpt

The S100 fused-type proteins (SFTPs) are thought to be involved in the barrier formation and function of the skin. Mutations in the profilaggrin gene, one of the best investigated members of this family, are known to be the major risk factors for ichthyosis vulgaris and atopic dermatitis. Recently, we identified human filaggrin-2 as a new member of the SFTP family. To achieve further insight into its function,...

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