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Article

Generation of pulmonary neuroendocrine cells and SCLC-like tumors from human embryonic stem cells

8 Feb 2019

Abstract excerpt

Cancer models based on cells derived from human embryonic stem cells (hESCs) may reveal why certain constellations of genetic changes drive carcinogenesis in specialized lineages. Here we demonstrate that inhibition of NOTCH signaling induces up to 10% of lung progenitor cells to form pulmonary neuroendocrine cells (PNECs), putative precursors to small cell lung cancers (SCLCs), and we can increase PNECs by...

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PMID: 30737256
DOI: 10.1084/jem.20181155

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