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Article

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

26 Jul 2024

Abstract excerpt

Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurrence of Tumor Protein P53 (TP53) and Retinoblastoma Transcriptional Corepressor 1 (RB1) mutations in their tumors, no therapeutic strategies are available to prevent or delay...

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PMID: 39054323
DOI: 10.1038/s41392-024-01908-y

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