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Article

Hedgehog signaling in cancer stem cells: a focus on hematological cancers

1 Jan 2015

Abstract excerpt

The stem cell paradigm was first demonstrated in hematopoietic stem cells. Whilst classically it was cytokines and chemokines which were believed to control stem cell fate, more recently it has become apparent that the stem cell niche and highly conserved embryonic pathways play a key role in governing stem cell behavior. One of these pathways, the hedgehog signaling pathway, found in all organisms, is vitally...

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PMID: 25691811
DOI: 10.2147/sccaa.s58613

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