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Targeting embryonic signaling pathways in cancer therapy

1 Jan 2012

Abstract excerpt

INTRODUCTION: The embryonic signaling pathways (ESP), Hedgehog, Notch and Wnt, are critical for the regulation of normal stem cells and cellular development processes. They are also activated in the majority of cancers. ESP are operational in putative cancer stem cells (CSC), which drive initial tumorigenesis and sustain cancer progression and recurrence in non-CSC bulk subpopulations. ESP represent novel...

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PMID: 22239436
DOI: 10.1517/14728222.2011.645808

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