Article

Compartmentalized Biosynthesis of Mycophenolic Acid

2019-01-18

Abstract excerpt

Mycophenolic acid (MPA) from filamentous fungi is the first natural product antibiotic in human history and a first-line immunosuppressive drug for organ transplantations and autoimmune diseases. However, its biosynthetic mechanisms have remained a long-standing mystery. Here, we elucidate the MPA biosynthetic pathway that features both compartmentalized enzymatic steps and unique cooperation between biosynthetic...

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Literature Corpus work: 75e93156-84a7-5c94-986a-68381f7b5849
DOI: 10.1101/524025

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