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Article

Efficient biotransformations using Escherichia coli with tolC acrAB mutations expressing cytochrome P450 genes.

Bioscience, biotechnology, and biochemistry - 23 Apr 2009

Fujii Tadashi, Fujii Yoshikazu, Machida Kazuhiro, Ochiai Atsushi, Ito Masashi

Abstract excerpt

We report here some efficient biotransformations using Escherichia coli strains with disruptions for the AcrAB-TolC efflux pump system. Biotransformations of compactin into pravastatin (6alpha-hydroxy-iso-compactin) were performed using E. coli strains with tolC and/or acrAB mutations expressing a cytochrome P450 (P450) gene. The production levels of pravastatin using strains with acrAB, tolC, and tolC acrAB...

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PMID: 19352031
DOI: 10.1271/bbb.80627

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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