Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Targeted disruption of <i>Adamts16</i> gene in a rat genetic model of hypertension

26 Nov 2012

Abstract excerpt

A disintegrin-like metalloproteinase with thrombospondin motifs-16 (Adamts16) is an important candidate gene for hypertension. The goal of the present study was to further assess the candidacy of Adamts16 by targeted disruption of this gene in a rat genetic model of hypertension. A rat model was generated by manipulating the genome of the Dahl Salt-sensitive (S) rat using zinc-finger nucleases, wherein the mutant...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Angiogenesis and VEGF in Cancer
Share to Antioxidant Activity and Oxidative Stress
Share to Cardiovascular Health and Disease Prevention

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23185005
DOI: 10.1073/pnas.1211290109

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Targeted disruption of <i>Adamts16</i> gene in a rat genetic model of hypertensionPMID 23185005Read ↗

Cryptorchidism and infertility in rats with targeted disruption of the Adamts16 locus.Semantic proximity Read ↗

Positional identification of variants of Adamts16 linked to inherited hypertension.Semantic proximity Read ↗

Candidate genes for hypertension: insights from the Dahl S rat.Semantic proximity Read ↗

Endothelial deletion of ADAM17 in mice results in defective remodeling of the semilunar valves and cardiac dysfunction in adultsSemantic proximity Read ↗

Contribution of ADAM17 and related ADAMs in cardiovascular diseasesSemantic proximity Read ↗

The distal carboxyl-terminal domains of ADAMTS13 are required for regulation of in vivo thrombus formationSemantic proximity Read ↗

Deficiency of MMP17/MT4-MMP proteolytic activity predisposes to aortic aneurysm in mice.Semantic proximity Read ↗

Heterozygous disruption of renal outer medullary potassium channel in rats is associated with reduced blood pressure.Semantic proximity Read ↗

Characterization of a novel variant in KCNJ16, encoding Kir5.1 channel.Semantic proximity Read ↗

Essential role of Kir5.1 channels in renal salt handling and blood pressure control.Semantic proximity Read ↗

Salt susceptibility maps to chromosomes 1 and 17 with sex specificity in the Sabra rat model of hypertension.Semantic proximity Read ↗

Cre/lox recombination in the lower urinary tractSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.