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Article

Role of the second disulfide bridge (Cys(18)-Cys(274)) in stabilizing the inactive AT₁ receptor.

Biological chemistry - 1 Oct 2010

Martin Renan Paulo, Rodrigues Eliete da Silva, Correa Silvana Aparecida Alves, Oliveira Suzana Macedo, Mortara Renato Arruda, Oliveira Laerte, Nakaie Clovis Ryuichi, Shimuta Suma Imura

Abstract excerpt

Previous research showed that disruption of the Cys(18)-Cys(274) bond in the angiotensin II (AngII) AT₁ receptor mutant (C18S), expressed in CHO cells, causes an increase in the basal activity and attenuation of the maximum response to AngII. In addition, this mutant was mostly intracellularly di...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 20707602
DOI: 10.1515/BC.2010.117

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20707602-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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