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Article

Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves.

Cardiovascular research - 1 Apr 2015

Mommersteeg Mathilda T M, Yeh Mason L, Parnavelas John G, Andrews William D

Abstract excerpt

AIMS: The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Slit-Robo signalling in the development of the murine membranous ventricular septum and cardiac...

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Source

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Identifiers

PMID: 25691540
DOI: 10.1093/cvr/cvv040
PMCID: PMC4362403

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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