Article
Single-nucleotide polymorphisms in the vascular endothelial growth factor pathway and outcomes of patients treated with first-line cytotoxic chemotherapy combined with bevacizumab for advanced colorectal cancer.
Oncology - 1 Jan 2014
Sohn Byeong Seok, Park Seong Joon, Kim Jeong Eun, Kim Kyu-Pyo, Hong Yong Sang, Suh Cheolwon, Kim Yong Sung, Kim Seon Young, Im Seock-Ah, Kim Sun Young, Kim Jee Hyun, Ahn Joong Bae, Park Young Suk, Kim Tae Won
Abstract excerpt
OBJECTIVE: The aim of this study was to evaluate the association between the efficacy of first-line cytotoxic chemotherapy plus bevacizumab and single-nucleotide polymorphisms (SNPs) of angiogenic genes in patients with advanced colorectal cancer (CRC). METHODS: DNA was extracted from blood samples of 125 patients, and 12 SNPs were evaluated for association with the objective response rate (ORR), progression-free...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.