Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.

doi:10.1038/srep25195

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Article

Angiogenesis genotyping and clinical outcome during regorafenib treatment in metastatic colorectal cancer patients.

Scientific reports - 27 Apr 2016

Giampieri Riccardo, Salvatore Lisa, Del Prete Michela, Prochilo Tiziana, D'Anzeo Marco, Loretelli Cristian, Loupakis Fotios, Aprile Giuseppe, Maccaroni Elena, Andrikou Kalliopi, Bianconi Maristella, Bittoni Alessandro, Faloppi Luca, Demurtas Laura, Montironi Rodolfo, Scarpelli Marina, Falcone Alfredo, Zaniboni Alberto, Scartozzi Mario, Cascinu Stefano

Abstract excerpt

Regorafenib monotherapy is a potential option for metastatic colorectal cancer patients. However, the lack of predictive factors and the severe toxicities related to treatment have made its use in clinical practice challenging. Polymorphisms of VEGF and its receptor (VEGFR) genes might regulate angiogenesis and thus potentially influence outcome during anti-angiogenesis treatment such as regorafenib. Aim of our...

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PMID: 27117754
DOI: 10.1038/srep25195
PMCID: PMC4846860

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