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Article

M2b Monocytes Provoke Bacterial Pneumonia and Gut Bacteria-Associated Sepsis in Alcoholics.

Journal of immunology (Baltimore, Md. : 1950) - 1 Dec 2015

Tsuchimoto Yusuke, Asai Akira, Tsuda Yasuhiro, Ito Ichiaki, Nishiguchi Tomoki, Garcia Melanie C, Suzuki Sumihiro, Kobayashi Makiko, Higuchi Kazuhide, Suzuki Fujio

Abstract excerpt

Chronic alcohol consumption markedly impairs host antibacterial defense against opportunistic infections. γ-irradiated NOD-SCID IL-2Rγ(null) mice inoculated with nonalcoholic PBMCs (control PBMC chimeras) resisted Klebsiella pneumonia and gut bacteria-associated sepsis, whereas the chimeras created with alcoholic PBMCs (alcoholic PBMC chimeras) were very susceptible to these infections. M1 monocytes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 26525287
DOI: 10.4049/jimmunol.1501369

Genes

CCL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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