Article
Correlation between N-acetyltransferase activities in uroepithelia and in vivo acetylator phenotype.
Drug metabolism and disposition: the biological fate of chemicals - 1 Jan 2000
Pink J C, Messing E M, Reznikoff C A, Bryan G T, Swaminathan S
Abstract excerpt
The relationship between in vivo acetylator phenotype of individuals and N-acetyltransferase (NAT) activity in the cytosol of their cultured uroepithelia was examined in four urology patients. In vivo acetylator phenotypes were assigned by determining the ratio of N-acetyl vs. total [N-acetyl+free] sulfamethazine in urine and blood following a single oral dose (1 gm) of sulfamethazine. From the same patients, a...
Topics
- Acetylation
- Acetyltransferases
- Adult
- Aminobiphenyl Compounds
- Humans
- Phenotype
- Urinary Bladder
- Urinary Bladder Neoplasms