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Article

kexB Gene Correlates With Aspergillus flavus Keratitis Severity: A Whole-Genome Analysis.

Investigative ophthalmology & visual science - 3 Feb 2025

Liu Jiamin, Kang Min, Wei Yuan, Zhang Zijun, Pang Jinding, Chen Qiankun, Xu Xizhan, Wei Zhenyu, Zhang Yang, Chen Kexin, Wang Zhiqun, Lu Xinxin, Liang Qingfeng

Abstract excerpt

Purpose: Fungal keratitis caused by Aspergillus flavus (A. flavus) can result in severe inflammation and corneal stromal melting, leading to visual impairment. This study aimed to identify virulent genes correlated with the severity of A. flavus keratitis using whole-genome sequencing. Methods: Whole-genome sequencing of 21 clinical A. flavus strains from cornea was performed to elucidate the pathogenesis of A....

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Identifiers

PMID: 39951298
DOI: 10.1167/iovs.66.2.42
PMCID: PMC11824512

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