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Article

Functional variants regulating LGALS1 (Galectin 1) expression affect human susceptibility to influenza A(H7N9).

Scientific reports - 17 Feb 2015

Chen Yu, Zhou Jie, Cheng Zhongshan, Yang Shigui, Chu Hin, Fan Yanhui, Li Cun, Wong Bosco Ho-Yin, Zheng Shufa, Zhu Yixin, Yu Fei, Wang Yiyin, Liu Xiaoli, Gao Hainv, Yu Liang, Tang Linglin, Cui Dawei, Hao Ke, Bossé Yohan, Obeidat Ma'en, Brandsma Corry-Anke, Song You-Qiang, To Kelvin Kai-Wang, Sham Pak Chung, Yuen Kwok-Yung, Li Lanjuan

Abstract excerpt

The fatality of avian influenza A(H7N9) infection in humans was over 30%. To identify human genetic susceptibility to A(H7N9) infection, we performed a genome-wide association study (GWAS) involving 102 A(H7N9) patients and 106 heavily-exposed healthy poultry workers, a sample size critically restricted by the small number of human A(H7N9) cases. To tackle the stringent significance cutoff of GWAS, we utilized an...

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Identifiers

PMID: 25687228
DOI: 10.1038/srep08517
PMCID: PMC4649671

Genes

LGALS1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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