Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

doi:10.1093/infdis/jiv246

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Article

Identification of TMPRSS2 as a Susceptibility Gene for Severe 2009 Pandemic A(H1N1) Influenza and A(H7N9) Influenza.

The Journal of infectious diseases - 15 Oct 2015

Cheng Zhongshan, Zhou Jie, To Kelvin Kai-Wang, Chu Hin, Li Cun, Wang Dong, Yang Dong, Zheng Shufa, Hao Ke, Bossé Yohan, Obeidat Ma'en, Brandsma Corry-Anke, Song You-Qiang, Chen Yu, Zheng Bo-Jian, Li Lanjuan, Yuen Kwok-Yung

Abstract excerpt

The genetic predisposition to severe A(H1N1)2009 (A[H1N1]pdm09) influenza was evaluated in 409 patients, including 162 cases with severe infection and 247 controls with mild infection. We prioritized candidate variants based on the result of a pilot genome-wide association study and a lung expression quantitative trait locus data set. The GG genotype of rs2070788, a higher-expression variant of TMPRSS2, was a...

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PMID: 25904605
DOI: 10.1093/infdis/jiv246
PMCID: PMC7107393

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TMPRSS2

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