Article
Host genetics and diet, but not immunoglobulin A expression, converge to shape compositional features of the gut microbiome in an advanced intercross population of mice.
Genome biology - 1 Jan 2014
Leamy Larry J, Kelly Scott A, Nietfeldt Joseph, Legge Ryan M, Ma Fangrui, Hua Kunjie, Sinha Rohita, Peterson Daniel A, Walter Jens, Benson Andrew K, Pomp Daniel
Abstract excerpt
BACKGROUND: Individuality in the species composition of the vertebrate gut microbiota is driven by a combination of host and environmental factors that have largely been studied independently. We studied the convergence of these factors in a G10 mouse population generated from a cross between two strains to search for quantitative trait loci (QTLs) that affect gut microbiota composition or ileal Immunoglobulin A...
Topics
- Animals
- Bacteria
- Diet
- Female
- Gastrointestinal Tract
- Genome, Bacterial
- Host-Pathogen Interactions
- Immunoglobulin A
- Male
- Mice
- Polymorphism, Single Nucleotide
- Quantitative Trait Loci
- Vertebrates