Article
The association of a nonsynonymous single-nucleotide polymorphism in TNFAIP3 with systemic lupus erythematosus and rheumatoid arthritis in the Japanese population.
Arthritis and rheumatism - 1 Feb 2010
Shimane Kenichi, Kochi Yuta, Horita Tetsuya, Ikari Katsunori, Amano Hirofumi, Hirakata Michito, Okamoto Akiko, Yamada Ryo, Myouzen Keiko, Suzuki Akari, Kubo Michiaki, Atsumi Tatsuya, Koike Takao, Takasaki Yoshinari, Momohara Shigeki, Yamanaka Hisashi, Nakamura Yusuke, Yamamoto Kazuhiko
Abstract excerpt
OBJECTIVE: Genome-wide association (GWA) studies in systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) in Caucasian populations have independently identified risk variants in and near the tumor necrosis factor alpha (TNFalpha)-induced protein 3 gene (TNFAIP3), which is crucial for the regulation of TNF-mediated signaling and Toll-like receptor signaling. The aim of this study was to assess the role...
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