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A simple-to-use method incorporating genomic markers into prostate cancer risk prediction tools facilitated future validation.

Journal of clinical epidemiology - 1 May 2015

Grill Sonja, Fallah Mahdi, Leach Robin J, Thompson Ian M, Hemminki Kari, Ankerst Donna P

Abstract excerpt

OBJECTIVES: To incorporate single-nucleotide polymorphisms (SNPs) into the Prostate Cancer Prevention Trial Risk Calculator (PCPTRC). STUDY DESIGN AND SETTING: A multivariate random-effects meta-analysis of likelihood ratios (LRs) for 30 validated SNPs was performed, allowing the incorporation of linkage disequilibrium. LRs for an SNP were defined as the ratio of the probability of observing the SNP in prostate...

Topics

Alleles
Biomarkers, Tumor
Case-Control Studies
Genetic Predisposition to Disease
Genome-Wide Association Study
Genotype
Humans
Likelihood Functions
Linkage Disequilibrium
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Multivariate Analysis

Polymorphism, Single Nucleotide

Prostatic Neoplasms

Risk

Source

Identifiers

PMID: 25684153
DOI: 10.1016/j.jclinepi.2015.01.006

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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