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Article

Functional mapping of the plant small RNA methyltransferase: HEN1 physically interacts with HYL1 and DICER-LIKE 1 proteins.

Nucleic acids research - 11 Mar 2015

Baranauskė Simona, Mickutė Milda, Plotnikova Alexandra, Finke Andreas, Venclovas Česlovas, Klimašauskas Saulius, Vilkaitis Giedrius

Abstract excerpt

Methylation of 3'-terminal nucleotides of miRNA/miRNA* is part of miRNAs biogenesis in plants but is not found in animals. In Arabidopsis thaliana this reaction is carried out by a multidomain AdoMet-dependent 2'-O-methyltransferase HEN1. Using deletion and structure-guided mutational analysis, we show that the double-stranded RNA-binding domains R(1) and R(2) of HEN1 make significant but uneven contributions to...

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PMID: 25680966
DOI: 10.1093/nar/gkv102
PMCID: PMC4357707

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