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Article

Is selection relevant in the evolutionary emergence of drug resistance?

Trends in microbiology - 1 Mar 2015

Day Troy, Huijben Silvie, Read Andrew F

Abstract excerpt

The emergence of drug-resistant pathogens is often considered a canonical case of evolution by natural selection. Here we argue that the strength of selection can be a poor predictor of the rate of resistance emergence. It is possible for a resistant strain to be under negative selection and still emerge in an infection or spread in a population. Measuring the right parameters is a necessary first step toward the...

Topics

Drug Resistance
Drug Resistance, Microbial
Evolution, Molecular
Genetic Fitness
Mutation
Plasmodium chabaudi
Selection, Genetic

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 25680587
DOI: 10.1016/j.tim.2015.01.005
PMCID: PMC4494118

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