Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Use of Induced Pluripotent Stem Cells to Recapitulate Pulmonary Alveolar Proteinosis Pathogenesis

26 Nov 2013

Abstract excerpt

RATIONALE: In patients with pulmonary alveolar proteinosis (PAP) syndrome, disruption of granulocyte/macrophage colony-stimulating factor (GM-CSF) signaling is associated with pathogenic surfactant accumulation from impaired clearance in alveolar macrophages. OBJECTIVES: The aim of this study was to overcome these barriers by using monocyte-derived induced pluripotent stem (iPS) cells to recapitulate...

Source

Identifiers

PMID: 24279752
DOI: 10.1164/rccm.201306-1039oc

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Use of Induced Pluripotent Stem Cells to Recapitulate Pulmonary Alveolar Proteinosis PathogenesisPMID 24279752Read ↗

Gene Correction of Human Induced Pluripotent Stem Cells Repairs the Cellular Phenotype in Pulmonary Alveolar ProteinosisSemantic proximity Read ↗

Murine iPSC-Derived Macrophages as a Tool for Disease Modeling of Hereditary Pulmonary Alveolar Proteinosis due to Csf2rb DeficiencySemantic proximity Read ↗

TALEN-mediated functional correction of human iPSC-derived macrophages in context of hereditary pulmonary alveolar proteinosisSemantic proximity Read ↗

Human pluripotent stem cell modeling of alveolar type 2 cell dysfunction caused by ABCA3 mutations.Semantic proximity Read ↗

Functional analysis and transcriptomic profiling of iPSC-derived macrophages and their application in modeling Mendelian disease.Semantic proximity Read ↗

Production and Characterization of Human Macrophages from Pluripotent Stem Cells.Semantic proximity Read ↗

Long-Term Safety and Efficacy of Gene-Pulmonary Macrophage Transplantation Therapy of PAP in Csf2ra−/− MiceSemantic proximity Read ↗

Pulmonary alveolar proteinosis caused by deletion of the GM-CSFRalpha gene in the X chromosome pseudoautosomal region 1.Semantic proximity Read ↗

Pulmonary transplantation of macrophage progenitors as effective and long-lasting therapy for hereditary pulmonary alveolar proteinosis.Semantic proximity Read ↗

Allogeneic Hematopoietic Stem Cell Transplantation After Prior Lung Transplantation for Hereditary Pulmonary Alveolar Proteinosis: A Case ReportSemantic proximity Read ↗

Familial pulmonary alveolar proteinosis caused by mutations in CSF2RA.Semantic proximity Read ↗

Pulmonary alveolar proteinosis: a review.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.