Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Evolutionary Fates of a Large Segmental Duplication in Mouse.

Genetics - 1 Sept 2016

Morgan Andrew P, Holt J Matthew, McMullan Rachel C, Bell Timothy A, Clayshulte Amelia M-F, Didion John P, Yadgary Liran, Thybert David, Odom Duncan T, Flicek Paul, McMillan Leonard, de Villena Fernando Pardo-Manuel

Abstract excerpt

Gene duplication and loss are major sources of genetic polymorphism in populations, and are important forces shaping the evolution of genome content and organization. We have reconstructed the origin and history of a 127-kbp segmental duplication, R2d, in the house mouse (Mus musculus). R2d contains a single protein-coding gene, Cwc22 De novo assembly of both the ancestral (R2d1) and the derived (R2d2) copies...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Wild
Share to Biological Evolution

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Conversion

Share to Gene Dosage

Share to Gene Duplication

Share to Genes, Duplicate

Share to RNA-Binding Proteins

Share to Segmental Duplications, Genomic

Source

Open in PubMed Open full text

Identifiers

PMID: 27371833
DOI: 10.1534/genetics.116.191007
PMCID: PMC5012392

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Evolutionary Fates of a Large Segmental Duplication in Mouse.PMID 27371833Read ↗

Mouse segmental duplication and copy number variation.Semantic proximity Read ↗

Genome-wide mapping and assembly of structural variant breakpoints in the mouse genome.Semantic proximity Read ↗

Primate segmental duplications: crucibles of evolution, diversity and disease.Semantic proximity Read ↗

Initial sequencing and comparative analysis of the mouse genome.Semantic proximity Read ↗

Enrichment of segmental duplications in regions of breaks of synteny between the human and mouse genomes suggest their involvement in evolutionary rearrangements.Semantic proximity Read ↗

Divergent genome evolution caused by regional variation in DNA gain and loss between human and mouseSemantic proximity Read ↗

Recent segmental duplications in the human genome.Semantic proximity Read ↗

R2d2 Drives Selfish Sweeps in the House Mouse.Semantic proximity Read ↗

The origins and impact of primate segmental duplications.Semantic proximity Read ↗

Recent duplication, domain accretion and the dynamic mutation of the human genome.Semantic proximity Read ↗

Gene duplication: a drive for phenotypic diversity and cause of human disease.Semantic proximity Read ↗

Rapid Evolution of the Fine-scale Recombination Landscape in Wild House Mouse (Mus musculus) Populations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.