Article
Genetic mapping and developmental timing of transmission ratio distortion in a mouse interspecific backcross.
BMC genetics - 3 Nov 2010
Eversley Chevonne D, Clark Tavia, Xie Yuying, Steigerwalt Jill, Bell Timothy A, de Villena Fernando P M, Threadgill David W
Abstract excerpt
BACKGROUND: Transmission ratio distortion (TRD), defined as statistically significant deviation from expected 1:1 Mendelian ratios of allele inheritance, results in a reduction of the expected progeny of a given genotype. Since TRD is a common occurrence within interspecific crosses, a mouse interspecific backcross was used to genetically map regions showing TRD, and a developmental analysis was performed to...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Female
- Genotype
- Hybridization, Genetic
- Inheritance Patterns
- Male
- Mice
- Mice, Inbred A
- Microsatellite Repeats
- Models, Genetic