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Article

Cre-mediated cell ablation contests mast cell contribution in models of antibody- and T cell-mediated autoimmunity.

Immunity - 23 Nov 2011

Feyerabend Thorsten B, Weiser Anne, Tietz Annette, Stassen Michael, Harris Nicola, Kopf Manfred, Radermacher Peter, Möller Peter, Benoist Christophe, Mathis Diane, Fehling Hans Jörg, Rodewald Hans-Reimer

Abstract excerpt

Immunological functions of mast cells remain poorly understood. Studies in Kit mutant mice suggest key roles for mast cells in certain antibody- and T cell-mediated autoimmune diseases. However, Kit mutations affect multiple cell types of both immune and nonimmune origin. Here, we show that targeted insertion of Cre-recombinase into the mast cell carboxypeptidase A3 locus deleted mast cells in connective and...

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Identifiers

PMID: 22101159
DOI: 10.1016/j.immuni.2011.09.015

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