Synonymous codon usage affects the expression of wild type and F508del CFTR.

Abstract excerpt

The cystic fibrosis transmembrane conductance regulator (CFTR) is an anion channel composed of 1480 amino acids. The major mutation responsible for cystic fibrosis results in loss of amino acid residue, F508 (F508del). Loss of F508 in CFTR alters the folding pathway resulting in endoplasmic-reticulum-associated degradation. This study investigates the role of synonymous codon in the expression of CFTR and CFTR...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Blotting, Northern
• Share to Chlorides
• Share to Cystic Fibrosis Transmembrane Conductance Regulator