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Article

Clinical application of whole-genome sequencing to inform treatment for multidrug-resistant tuberculosis cases.

Journal of clinical microbiology - 1 May 2015

Witney Adam A, Gould Katherine A, Arnold Amber, Coleman David, Delgado Rachel, Dhillon Jasvir, Pond Marcus J, Pope Cassie F, Planche Tim D, Stoker Neil G, Cosgrove Catherine A, Butcher Philip D, Harrison Thomas S, Hinds Jason

Abstract excerpt

The treatment of drug-resistant tuberculosis cases is challenging, as drug options are limited, and the existing diagnostics are inadequate. Whole-genome sequencing (WGS) has been used in a clinical setting to investigate six cases of suspected extensively drug-resistant Mycobacterium tuberculosis (XDR-TB) encountered at a London teaching hospital between 2008 and 2014. Sixteen isolates from six suspected XDR-TB...

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PMID: 25673793
DOI: 10.1128/JCM.02993-14
PMCID: PMC4400773

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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