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Article

Microfluidic linear hydrogel array for multiplexed single nucleotide polymorphism (SNP) detection.

Analytical chemistry - 17 Mar 2015

Jung Yun Kyung, Kim Jungkyu, Mathies Richard A

Abstract excerpt

A PDMS-based microfluidic linear hydrogel array is developed for multiplexed single nucleotide polymorphism (SNP) detection. A sequence of three-dimensional (3D) hydrogel plugs containing the desired DNA probes is prepared by UV polymerization within a PDMS microchannel system. The fluorescently labeled target DNA is then electrophoresed through the sequence of hydrogel plugs for hybridization. Continued...

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PMID: 25673175
DOI: 10.1021/ac5048696

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