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Microfabricated linear hydrogel microarray for single-nucleotide polymorphism detection.

Analytical chemistry - 17 Jan 2012

Bromberg Avraham, Jensen Erik C, Kim Jungkyu, Jung Yun Kyung, Mathies Richard A

Abstract excerpt

A platform is developed for rapid, multiplexed detection of single-nucleotide polymorphisms using gels copolymerized with oligonucleotide capture probes in a linear microchannel array. DNA samples are analyzed by electrophoresis through the linear array of gels, each containing 20-40 μM of a unique oligonucleotide capture probe. Electrophoresis of target DNA through the capture sites and the high concentration of...

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PMID: 22145681
DOI: 10.1021/ac202303f

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