Microfluidics for the deposition of density gradients of immobilized oligonucleotide probes; developing surfaces that offer spatial control of the stringency of DNA hybridization.

Abstract excerpt

A method for the development of continuous density gradients of immobilized oligonucleotide probes (20mer) along the length of microfluidic channels is demonstrated. The development of continuous density gradients was achieved using variable electrokinetic transport of probes in hybrid glass-polydimethylsiloxane microfluidic chips. The probes were terminated with an amine functional group, and were delivered by...

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