Article
Crystallographic structure of a rheumatoid arthritis MHC susceptibility allele, HLA-DR1 (DRB1*0101), complexed with the immunodominant determinant of human type II collagen.
Journal of immunology (Baltimore, Md. : 1950) - 15 Sept 2006
Rosloniec Edward F, Ivey Robert A, Whittington Karen B, Kang Andrew H, Park Hee-Won
Abstract excerpt
The expression of HLA-DR1 (DRB1*0101) is associated with an enhanced risk for developing rheumatoid arthritis (RA). To study its function, we have solved the three-dimensional structure of HLA-DR1 complexed with a candidate RA autoantigen, the human type II collagen peptide CII (259-273). Based on these structural data, the CII peptide is anchored by Phe263 at the P1 position and Glu266 at P4. Surprisingly, the...
Topics
- Alleles
- Arthritis, Rheumatoid
- Collagen Type II
- Crystallography, X-Ray
- Genetic Predisposition to Disease
- HLA-A Antigens
- HLA-DRB1 Chains
- Humans
- Immunodominant Epitopes
- Peptide Fragments