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Article

Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia.

Neurobiology of aging - 1 Apr 2015

Karlsson Ida K, Bennet Anna M, Ploner Alexander, Andersson Therese M-L, Reynolds Chandra A, Gatz Margaret, Pedersen Nancy L

Abstract excerpt

To investigate how apolipoprotein E (APOE) affects the temporal relationship between depression and dementia, we conducted a nested case-control study with longitudinal depression and dementia evaluations from several population studies by using 804 dementia cases and 1600 matched controls, totaling 1519 unique individuals. Depression within 10 years of onset of dementia was strongly associated with dementia...

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Identifiers

PMID: 25670333
DOI: 10.1016/j.neurobiolaging.2015.01.008
PMCID: PMC4380668

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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