Article
APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression.
International journal of geriatric psychiatry - 1 Dec 2003
Butters Meryl A, Sweet Robert A, Mulsant Benoit H, Ilyas Kamboh M, Pollock Bruce G, Begley Amy E, Reynolds Charles F, DeKosky Steven T
Abstract excerpt
OBJECTIVE: There is a recognized but poorly understood relationship between late-life depression (LLD) and progressive dementia. Both cognitive impairment co-occurring with LLD and a late age-of-onset of first lifetime depressive episode appear to be associated with subsequent progressive dementia. A history of major depression, especially when the first onset occurs in late-life, has been identified as a risk...
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