Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The ACE Gene Is Associated with Late-Life Major Depression and Age at Dementia Onset in a Population-Based Cohort.

The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry - 1 Feb 2017

Zettergren Anna, Kern Silke, Gustafson Deborah, Gudmundsson Pia, Sigström Robert, Östling Svante, Eriksson Elias, Zetterberg Henrik, Blennow Kaj, Skoog Ingmar

Abstract excerpt

OBJECTIVE: Depression and dementia in the elderly have been suggested to share similar risk factors and pathogenetic background, and recently the authors reported that the APOEɛ4 allele is a risk factor for both disorders in the general population. The aim of the present study was to examine the influence of the well-known polymorphisms rs1799752 in the angiotensin-converting enzyme (ACE) and rs5186 in the...

Read the complete abstract on PubMed

Topics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share this publication in a Topic to start or enrich a Post.

Share to Age of Onset
Share to Cross-Sectional Studies
Share to Dementia
Share to Depressive Disorder, Major
Share to Logistic Models
Share to Peptidyl-Dipeptidase A
Share to Receptor, Angiotensin, Type 1
Share to Sweden

Source

Identifiers

PMID: 27639288
DOI: 10.1016/j.jagp.2016.06.009

Genes

ACE
AGTR1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The ACE Gene Is Associated with Late-Life Major Depression and Age at Dementia Onset in a Population-Based Cohort.PMID 27639288Read ↗

Behavioural effects of the ACE insertion/deletion polymorphism in Alzheimer's disease depend upon stratification according to APOE-ϵ4 carrier status.Semantic proximity Read ↗

APOE is associated with age-of-onset, but not cognitive functioning, in late-life depression.Semantic proximity Read ↗

Absolute 10-year risk of dementia by age, sex and APOE genotype: a population-based cohort study.Semantic proximity Read ↗

Apolipoprotein E ε4 genotype and the temporal relationship between depression and dementia.Semantic proximity Read ↗

Late-onset depression: genetic, vascular and clinical contributions.Semantic proximity Read ↗

ApoE4 and late onset depression in Indian population.Semantic proximity Read ↗

A family study of Alzheimer disease and early- and late-onset depression in elderly patients.Semantic proximity Read ↗

Depressive symptoms and APOE polymorphisms in an elderly population-based sample.Semantic proximity Read ↗

Depression and dementia in relation to apolipoprotein E polymorphism in a population sample age 75+.Semantic proximity Read ↗

Angiotensin-converting enzyme gene variants are associated with both cortisol secretion and late-life depression.Semantic proximity Read ↗

Apolipoprotein E gene, environmental risk factors, and their interactions in dementia among seniors.Semantic proximity Read ↗

Depression as a risk factor or prodromal feature for dementia? Findings in a population-based sample of Swedish twins.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.