Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.

doi:10.1016/j.ccell.2015.01.003

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Article

Recurrent DGCR8, DROSHA, and SIX homeodomain mutations in favorable histology Wilms tumors.

Cancer cell - 9 Feb 2015

Walz Amy L, Ooms Ariadne, Gadd Samantha, Gerhard Daniela S, Smith Malcolm A, Guidry Auvil Jaime M, Guidry Auvil Jamie M, Meerzaman Daoud, Chen Qing-Rong, Hsu Chih Hao, Yan Chunhua, Nguyen Cu, Hu Ying, Bowlby Reanne, Brooks Denise, Ma Yussanne, Mungall Andrew J, Moore Richard A, Schein Jacqueline, Marra Marco A, Huff Vicki, Dome Jeffrey S, Chi Yueh-Yun, Mullighan Charles G, Ma Jing, Wheeler David A, Hampton Oliver A, Jafari Nadereh, Ross Nicole, Gastier-Foster Julie M, Perlman Elizabeth J

Abstract excerpt

We report the most common single-nucleotide substitution/deletion mutations in favorable histology Wilms tumors (FHWTs) to occur within SIX1/2 (7% of 534 tumors) and microRNA processing genes (miRNAPGs) DGCR8 and DROSHA (15% of 534 tumors). Comprehensive analysis of 77 FHWTs indicates that tumors with SIX1/2 and/or miRNAPG mutations show a pre-induction metanephric mesenchyme gene expression pattern and are...

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Identifiers

PMID: 25670082
DOI: 10.1016/j.ccell.2015.01.003
PMCID: PMC4800737

Genes

DGCR8
DROSHA
SIX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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