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Article

Single-nucleotide polymorphisms in p53 pathway and aggressiveness of prostate cancer in a Caucasian population.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Nov 2010

Sun Tong, Lee Gwo-Shu Mary, Oh William K, Pomerantz Mark, Yang Ming, Xie Wanling, Freedman Matthew L, Kantoff Philip W

Abstract excerpt

PURPOSE: The tumor suppressor p53 plays a crucial role in maintaining genomic stability and tumor prevention. Mdm2, Mdm4, and Hausp are all critical regulators of the p53 protein. Despite the importance of the p53 pathway in prostate cancer development and progression, little is known about the association of functional single-nucleotide polymorphisms (SNP) in the p53 pathway genes and prostate cancer...

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Identifiers

PMID: 20855462
DOI: 10.1158/1078-0432.CCR-10-1261
PMCID: PMC2970725

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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